(Updated: 09/07/2025)
Complete list of our publications: Google Scholar PubMed
2025
Fan M, Tsai CW*, Zhang J, Zhang J, Krishnan AR, Liu TY, Huan YL, Aydin D, Du S, Sobecks BL, Rodriguez XM, Reiter AH, Bertozzi CR, Dror RO, Tsai MF*, & Liang F*.
Structure and mechanism of the mitochondrial calcium transporter NCLX.
Nature. In press. *Co-corresponding authors.
Zhang JL, Chang YC, Lai PH, Yeh HI, Tsai CW, Huang YL, Liu TY, Lee IC, Foulon N, Xu Y, Rao B, Shih HM, Tu YC, Reyes AV, Xu SL, Feng L, & Tsai MF.
TMEM65 functions as the mitochondrial Na+/Ca2+ exchanger.
Nature Cell Biology. 27: 1301-1310.
Tu YC, Lee IC, Chang TW, Lee V, Chao FY, Geltser ER, & Tsai MF.
Mechanisms of dual modulatory effects of spermine on the mitochondrial calcium uniporter complex.
Journal of Biological Chemistry. 301: 108218.
2024
He Z#, Tu YC#, Tsai CW, Mount J, Zhang J, Tsai MF*, & Peng Y*.
Structure and function of the human MRS2 channel.
Nature Structural & Molecular Biology. 32: 459-468. *Co-corresponding authors.
2023
Tsai CW, Liu TY, Chao FY, Tu YC, Rodriguez MX, Van Keuren AM, Ma Z, Bankston J, & Tsai MF.
Evidence supporting the MICU1 occlusion mechanism and against the potentiation model in the mitochondrial calcium uniporter complex.
Proc Natl Acad Sci U S A. 120: e2217665120.
2022
Tsai CW, Rodriguez MX, Van Keuren AM, Phillips CP, Shushunov HM, Lee JE, Garcia AM, Ambardekar AV, Cleveland JC, Reisz JA, Proenza C, Chatfield KC, & Tsai MF.
Mechanisms and significance of tissue-specific MICU regulation of the mitochondrial calcium uniporter complex.
Molecular Cell. 82: 3661–3676.
2021
Rodriguez MX, Van Keuren AM, & Tsai MF.
Quantitative assays to measure the transport activity of the mitochondrial calcium uniporter in cell lines or Xenopus oocytes.
STAR Protocols. 2: 100979.
Woods JJ, Rodriguez MX, Tsai CW, Tsai MF, & Wilson JJ.
Cobalt amine complexes and Ru265 interact with the DIME region of the mitochondrial calcium uniporter.
Chemical Communications. 57: 6161-6164.
2020
Van Keuren AM, Tsai CW, Balderas E, Rodriguez MX, Chaudhuri D, & Tsai MF.
Mechanisms of EMRE-dependent MCU opening in the mitochondrial calcium uniporter complex.
Cell Reports. 33: 108486.
Fan M, Zhang J, Tsai CW, Orlando BJ, Rodriguez MX, Xu Y, Liao M, *Tsai MF, & *Feng L.
Structure and mechanism of the mitochondrial Ca2+ uniporter holocomplex.
Nature. 582: 129-133. *Co-corresponding authors.
2019
Phillips CB, Tsai CW, & Tsai MF.
The Conserved Aspartate Ring of MCU Mediates MICU1 Binding and Regulation in the Mitochondrial Calcium Uniporter Complex.
eLife. 8: e41112.
Selected publications before 2019
Tsai CW & Tsai MF.
Electrical Recordings of the Mitochondrial Calcium Uniporter in Xenopus Oocytes.
Journal of General Physiology. (2018) 150: 1035-1043.
Tsai CW, Wu Y, Pao PC, Phillips CB, Williams C, Miller C, Ranaghan M, & Tsai MF.
Proteolytic Control of the Mitochondrial Calcium Uniporter Complex.
Proc Natl Acad Sci U S A. (2017) 114: 4388-4393.
Tsai MF, Phillips CB, Ranaghan M, Tsai CW, Williams C, & Miller C.
Dual Functions of a Small Regulatory Subunit in the Mitochondrial Calcium Uniporter.
eLife. (2016) 5: e15545.
Tsai MF & Miller C.
Building a Temperature-Sensitive Ion Channel.
Cell. (2014) 158: 977-979
Tsai MF, Jiang D, Zhao L, Clapham DE, & Miller C.
Functional Reconstitution of the Mitochondrial H+/Ca2+ Exchanger Letm1.
Journal of General Physiology. (2014) 143: 67-73.
Tsai MF, McCarthy P, & Miller C.
Substrate Selectivity in Glutamate-Dependent Acid Resistance in Enteric Bacteria.
Proc Natl Acad Sci U S A. (2013) 110: 5898-5902.
Tsai MF & Miller C.
Substrate Selectivity in Arginine-Dependent Acid Resistance in Enteric Bacteria.
Proc Natl Acad Sci U S A. (2013) 110: 5893-5897.
Tsai MF, Fang Y, & Miller C.
Sided Functions of an Arginine-Agmatine Antiporter Oriented in Liposomes.
Biochemistry. (2012) 52: 1577-1585.
Tsai MF, Jih KY, Shimizu H, Li M, & Hwang TC.
Optimization of the Degenerated Interfacial ATP Binding Site Improves the Function of Disease-Related Mutant Cystic Fibrosis Transmembrane Conductance Regulator Channels.
Journal of Biological Chemistry. (2010) 285: 37663-37671.
Tsai MF, Li M, & Hwang TC.
Stable ATP Binding Mediated by a Partial NBD Dimer of the CFTR Chloride Channel.
Journal of General Physiology. (2010) 135: 399-414.