Tsai Lab

Membrane-Transport Mechanisms and Molecular Physiology

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Publication

Complete list of our publications: Google Scholar PubMed

2020

VanKeuren AM, Tasi CW, Balderas E, Rodriguez M, Chaudhuri D, & Tsai MF.
Mechanisms of EMRE-dependent MCU opening in the mitochondrial calcium uniporter complex.
Cell Reports. (in press).

Fan M, Zhang J, Tasi CW, Orlando BJ, Rodriguez M, Xu Y, Liao M, *Tsai MF, & *Liang F.
Structure and mechanism of the mitochondrial Ca2+ uniporter holocomplex.
Nature. 582: 129-133. (*co-corresponding authors).

2019

Phillips CB, Tsai CW, & Tsai MF.
The Conserved Aspartate Ring of MCU Mediates MICU1 Binding and Regulation in the Mitochondrial Calcium Uniporter Complex.
eLife. 8: e41112.

2018

Tsai CW & Tsai MF.
Electrical Recordings of the Mitochondrial Calcium Uniporter in Xenopus Oocytes.
Journal of General Physiology. 150: 1035-1043.

2017

Tsai CW, Wu Y, Pao PC, Phillips CB, Williams C, Miller C, Ranaghan M, & Tsai MF.
Proteolytic Control of the Mitochondrial Calcium Uniporter Complex.
Proc Natl Acad Sci U S A. 114: 4388-4393.

Selected publications before 2016

Tsai MF, Phillips CB, Ranaghan M, Tsai CW, Williams C, & Miller C.
Dual Functions of a Small Regulatory Subunit in the Mitochondrial Calcium Uniporter.
eLife. (2016) 5: e15545.

Tsai MF, & Miller C.
Building a Temperature-Sensitive Ion Channel.
Cell. (2015) 158: 977-979

Tsai MF, Jiang D, Zhao L, Clapham D, & Miller C.
Functional Reconstitution of the Mitochondrial H+/Ca2+ Exchanger Letm1.
Journal of General Physiology. (2014) 143: 67-73.

Tsai MF, McCarthy P, & Miller C.
Substrate Selectivity in Glutamate-Dependent Acid Resistance in Enteric Bacteria.
Proc Natl Acad Sci U S A. (2013) 110: 5898-5902.

Tsai MF, & Miller C.
Substrate Selectivity in Arginine-Dependent Acid Resistance in Enteric Bacteria.
Proc Natl Acad Sci U S A. (2013) 110: 5893-5897.

Tsai MF, Fang Y, & Miller C.
Sided Functions of an Arginine-Agmatine Antiporter Oriented in Liposomes.
Biochemistry. (2012) 52: 1577-1585.

Tsai MF, Jih KY, Shimizu H, Li M, & Hwang TC.
Optimization of the Degenerated Interfacial ATP Binding Site Improves the Function of Disease-Related Mutany Cystic Fibrosis Transmembrane Conductance Regulator Channels.
Journal of Biological Chemistry. (2010) 285: 37663-37671.

Tsai MF, Li M, & Hwang TC.
Stable ATP Binding Mediated by a Partial NBD Dimer of the CFTR Chloride Channel.
Journal of General Physiology. (2010) 135: 399-414.

Lab News

Nov 2, 2020
Anna reached an important milestone in her PhD study: first lead-author paper accepted (Cell Reports) “Mechanisms of EMRE-dependent opening in the mitochondrial calcium uniporter complex.”

May 20, 2020
New paper published in Nature.
“Structure and mechanisms of the mitochondrial calcium uniporter holocomplex.”
https://rdcu.be/b4iEz

June 15, 2019
Maddy joined the lab.

Jan 7, 2019
New paper accepted in eLife.
“The conserved aspartate ring of MCU mediates MICU1 binding and regulation in the mitochondrial calcium uniporter complex.” Link

Jan 2, 2019
Our lab in the University of Colorado officially opens! Anna joined the lab.

Aug 29, 2018
The lab obtained the first R01 support!
R01-GM129345

Contact

  • ming-feng.tsai@ucdenver.edu
  • 303-724-4106
  • Room 7105, Research Complex 1-North
    12800 E 19th St., Aurora, CO 80045
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